Hydrolysis of hydroxybenzoate saxitoxin analogues originating from Gymnodinium catenatum |
| |
Authors: | Paulo Vale |
| |
Affiliation: | Instituto Nacional dos Recursos Biológicos, I.P./L-IPIMAR, Avenida de Brasília s/n, 1449-006 Lisbon, Portugal |
| |
Abstract: | The paralytic shellfish poisoning (PSP) toxin producer Gymnodinium catenatum produces several hydrophobic analogues of saxitoxin (STX). These are poorly studied due to their recent discovery and lack of standards. It was previously observed these hydrophobic analogues could be partially hydrolysed, loosing its benzoate moiety during alkaline oxidation to obtain fluorescent products measurable by HPLC analysis. The hydrolysis reaction was further explored to study two practical aspects. One was the indirect measurement of these compounds through its hydrolysis products: the decarbamoyl analogues of STX. The second one was to simplify standard production of decarbamoyl analogues, which are commonly found in contaminated shellfish products. |
| |
Keywords: | Gymnodinium catenatum GC toxins Hydroxybenzoate toxins Hydrolysis HILIC&ndash MS Saxitoxins |
本文献已被 ScienceDirect 等数据库收录! |