Antioxidant properties and chemical composition of technical Cashew Nut Shell Liquid (tCNSL) |
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| Authors: | Teresinha de Jesus Aguiar dos Santos Andrade Bruno Quirino Araújo Antonia Maria das Graças Lopes Citó Juliana da Silva Jenifer Saffi Marc François Richter Alexandre de Barros Falcão Ferraz |
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| Affiliation: | 1. Laboratório de Genética Toxicologia, Instituto Federal de Educação Tecnologia do Piauí, Teresina, PI, Brazil;2. Laboratório de Química de Produtos Naturais, Departamento de Química, Universidade Federal do Piauí (UFPI), Teresina, PI, Brazil;3. Programa de Pós-Graduação em Genética e Toxicologia Aplicada (PPGGTA), Universidade Luterana do Brasil (ULBRA), Canoas, RS, Brazil;4. Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil;5. Instituto Nacional para Pesquisa Translacional em Saúde e Ambiente na Região Amazônica, Conselho Nacional de Desenvolvimento Científico e Technológico/MCT, Brazil |
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| Abstract: | The present study analysed the antioxidant activity of the technical Cashew Nut Shell Liquid (tCNSL) using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay and the xanthine oxidase assay, as well as in vivo evaluation by Saccharomycescerevisiae assay. Also, the chemical composition of tCNSL was determined by gas chromatography–mass spectrometry (GC–MS), revealing the presence of cardanols (40.26%), cardols (29.95%), phytosterol (10.68%), triacontanes (4.66%) and anacardic acid (1.79%). The DPPH-based assay results showed that tCNSL 1000 μg/ml reduced the radical level by 88.9%, and the scavenging of hydroxyl radicals in the xanthine oxidase assay indicated significant antioxidant activity (IC50 = 702 μg/ml). In addition, tCNSL exerts an important protective effect against oxidative stress in yeast when used in 100–500 μg/ml concentration range, when exposed to paraquat or H2O2, indicating an in vivo antioxidant effect. |
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| Keywords: | Technical Cashew Nut Shell Liquid (tCNSL) Industrial Antioxidant activity DPPH Xanthine oxidase Saccharomyces cerevisae Gas chromatography |
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