Dual effect of free and liposomal forms of phenolic lipids on the activity of GPI-anchor-deprived acetylcholinesterase from erythrocytes |
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Authors: | Maria Stasiuk Magdalena KletaArkadiusz Kozubek |
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Affiliation: | Department of Lipids and Liposomes, Faculty of Biotechnology, University of Wroclaw, Przybyszewskiego 63/77, 51-148 Wroclaw, Poland |
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Abstract: | The effect of free and liposomal forms of phenolic lipids isolated from rye grains, cashew nut-shell liquid (CNSL) from Anacardium occidentale, and Merrulius tremellosus fruit body on the glycosyl-phosphatidylinositol (GPI)-anchor-deprived erythrocyte-ghost acetylcholinesterase activity was studied. It was shown that the observed effect distinctly depends on the form of the phenolic lipids available for interaction with the enzyme. The free form of the phenolic lipids decreased the enzymatic activity of GPI-anchor-deprived acetylcholinesterase less than the acetylcholinesterase anchored in erythrocytes ghosts, whereas the same phenolic lipids present in the medium in liposomal form, increased it. |
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Keywords: | AChE acetylcholinesterase EPC egg yolk phosphatidylcholine CNSL Cashew Nut-Shell Liquid from Anacardium occidentale DTNB 5 5&prime -dithio-bis (2-nitrobenzoic acid) GPI glycosyl-phosphatidylinositol |
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