Monitoring the functionalization of single-walled carbon nanotubes with chitosan and folic acid by two-dimensional diffusion-ordered NMR spectroscopy |
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| Authors: | John J. Castillo Mary H. Torres Daniel R. Molina Jaime Castillo-León Winnie E. Svendsen Patricia Escobar Fernando Martínez O. |
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| Affiliation: | 1. Centro de Investigaciones en Catálisis, Universidad Industrial de Santander, Sede Guatiguará UIS Km 2 vía Refugio, Piedecuesta, Colombia;2. Laboratorio de Resonancia Magnética Nuclear, Universidad Industrial de Santander, Sede Guatiguará UIS Km 2 vía Refugio, Piedecuesta, Colombia;3. Department of Micro and Nanotechnology, Technical University of Denmark, 2800 Lyngby, Denmark;4. Centro de Investigaciones en Enfermedades Tropicales, Universidad Industrial de Santander, Sede Guatiguará UIS Km 2 vía Refugio, Piedecuesta, Colombia |
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| Abstract: | A conjugate between single-walled carbon nanotubes, chitosan and folic acid has been prepared. It was characterized by diffusion ordered two-dimensional hydrogen-1 nuclear magnetic resonance and hydrogen-1 nuclear magnetic resonance spectroscopy which revealed the presence of a conjugate that was generated by the linkage between the carboxyl moiety of the folic acid and the amino group of the chitosan, which in turn was non-covalently bound to the single-walled carbon nanotubes. The obtained diffusion coefficient values demonstrated that free folic acid diffused more rapidly than the folic acid conjugated to single-walled carbon nanotubes–chitosan. The values of the proton signal of hydrogen-1 nuclear magnetic resonance spectroscopy and two-dimensional hydrogen-1 nuclear magnetic resonance spectroscopy further confirmed that the folic acid was conjugated to the chitosan, wrapping the single-walled carbon nanotubes. |
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