Distribution of Etoposide-Loaded Hydrophilic Albumin Microspheres in Mice |
| |
Authors: | H. R. Ravikumar S. A. Dhanaraj D. Rajendran Rajeev Dube B. Suresh |
| |
Affiliation: | a Division of Research, J.S.S. College of Pharmacy, Rocklands, Ootacamund, India |
| |
Abstract: | Hydrophilic albumin microspheres of etoposide were prepared by the emulsion polymerization technique using glutaraldehyde as the cross-linking agent. The microspheres prepared had a mean diameter of 1.5 μm. The microspheres were injected into mice by the intravenous route. In all, 12 mice were selected for the study, out of which 10 were given the drug-loaded microspheres and 2 were kept as solvent control. The mice were sacrificed after 24 hr and the accumulation of drug was determined in lungs, liver, and kidney. |
| |
Keywords: | |
本文献已被 InformaWorld 等数据库收录! |
|