| 5-(2-氨基-4-氯苯基)四氮唑的合成 |
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| 引用本文： | 李付刚. 5-(2-氨基-4-氯苯基)四氮唑的合成[J]. 精细与专用化学品, 2006, 14(14): 15-16 |
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| 作者姓名： | 李付刚 |
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| 作者单位： | 沈阳化工研究院,辽宁,沈阳,110021 |
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| 摘 要： | 4-氯-2-硝基苯甲酸用甲基磺酰胺与五氯化磷氰化,铂炭催化剂存在下加氢还原得2-氨基-4-氯苯甲腈,接着与叠氮化钠成四唑环合成5-(2-氨基-4-氯苯基)四氮唑;以4-氯-2-硝基苯甲酸计,产品总收率70%,含量99%(HPLC法),产品经IR,1HNMR,MS测定,表明结构正确。
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| 关 键 词： | 四氮唑 2-氨基-4-氯苯腈 4-氯-2-硝基苯甲酸 |
| 修稿时间： | 2005-12-08 |
Synthesis of 5-( 2-Amino-4-chlorophenyl ) tetrazole |
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| LI Fu-gang. Synthesis of 5-( 2-Amino-4-chlorophenyl ) tetrazole[J]. Fine and Specialty Chemicals, 2006, 14(14): 15-16 |
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| Authors: | LI Fu-gang |
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| Abstract: | 2-Amino-4-chlorocyanobenzene was prepared from 4-chloro-2-nitrobenzoic acid by cyanidation of methyl sulfonylamide and phosphorus pentachloride at first, then hydrogenation was carried out in the presence of Pt-C catalyst. After that the 2-amino-4-chlorocyanobenzene was reacted with sodium azide to form cyclic tetrazole i.e. 5-(2-amino-4-chloro)phenyltetrazole, the final product was obtained with a total yield of 70%, calculated based on 4-chloro-2-nitrobenzoic acid. The content of title product was 99% proved by HPLC. The structure of 5-(2-amino-4-chloro) phenyltetrazole was confirmed by IR, ~1HNMR and MS. |
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| Keywords: | tetrazole 2-amino-4-chlorocyanobenzene 4-chloro-2-nitrobenzoic acid |
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