| 1-甲基-吡唑-3-羧酸的合成研究 |
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| 引用本文： | 张正,李孝琼,杨盟辉,段远富,田应仟.1-甲基-吡唑-3-羧酸的合成研究[J].广州化工,2011,39(18):72-73,96. |
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| 作者姓名： | 张正 李孝琼 杨盟辉 段远富 田应仟 |
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| 作者单位： | 中国人民解放军61699部队,湖北武汉,430070 |
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| 摘 要： | 以3-甲基吡唑为原料,通过氧化和甲基化反应两步反应得到1-甲基-吡唑-3-羧酸,总收率32.2%。考察了反应时间、反应温度、物料配比等条件对产率的影响,优化了反应条件,并用红外光谱和液相色谱对目标化合物进行了表征。
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| 关 键 词： | 1-甲基-吡唑-3-羧酸 氧化 甲基化 合成 |
Research on the Synthesis of 1-methyl-pyrazole-3-carboxylic Acid |
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| ZHANG Zheng,LI Xiao-qiong,YANG Meng-hui,DUAN Yuan-fu.Research on the Synthesis of 1-methyl-pyrazole-3-carboxylic Acid[J].GuangZhou Chemical Industry and Technology,2011,39(18):72-73,96. |
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| Authors: | ZHANG Zheng LI Xiao-qiong YANG Meng-hui DUAN Yuan-fu |
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| Affiliation: | (Unit No.61699,The People’s Liberation Army,Hubei Wuhan 430070,China) |
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| Abstract: | 1-methyl-pyrazole-3-carboxylic acid was synthesized using 3-methylpyrazole as raw material by twostep reaction of oxidation and methylation in 32.2% total yield.The effects of reaction time,reaction temperature and ratio of materials were investigated and optimized.The structure of target compound was confirmed by IR spectrum and liquid chromatography. |
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| Keywords: | 1-methyl-pyrazole-3-carboxylic acid oxidation methylation synthesis |
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