| 2-乙基-4-七氟异丙基苯胺的合成 |
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| 引用本文： | 沈佳萍,罗亦婷,李舒婷,胡华南.2-乙基-4-七氟异丙基苯胺的合成[J].广州化工,2011,39(17):65-66. |
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| 作者姓名： | 沈佳萍 罗亦婷 李舒婷 胡华南 |
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| 作者单位： | 台州学院医药化工学院,浙江临海,317000 |
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| 摘 要： | 以连二亚硫酸钠为引发剂,在苯环上通过自由基亲电取代反应引入七氟异丙基,合成2-乙基-4-七氟异丙基苯胺,研究各种条件对反应的速度和收率的影响。最佳结果为：2-乙基苯胺与七氟异丙基碘的物质的量比为1∶1.2,连二亚硫酸钠和碳酸氢钠的物质的量分别为2-乙基苯胺的1.2倍,相转移催化剂四丁基硫酸氢铵与2-乙基苯胺的物质的量比为0.1,反应温度为10～20℃。
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| 关 键 词： | 七氟异丙基 2-乙基苯胺 七氟异丙基碘 2-乙基-4-七氟异丙基苯胺 |
Synthesis of 2-ethyl-4-heptafluoroisopropylaniline |
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| SHEN Jia-ping,LUO Yi-ting,LI Shu-ting,HU Hua-nan.Synthesis of 2-ethyl-4-heptafluoroisopropylaniline[J].GuangZhou Chemical Industry and Technology,2011,39(17):65-66. |
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| Authors: | SHEN Jia-ping LUO Yi-ting LI Shu-ting HU Hua-nan |
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| Affiliation: | (School of Pharmaceutical and Chemical Engineering,Taizhou University,Zhejiang Linhai 317000,China) |
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| Abstract: | 2-ethyl-4-heptafluoroisopropylaniline was synthesized by using sodium hyposulfite as initiator and importing heptafluoroisopropyl by free radical electrophilic substitution in the benzene ring.The factors affected the reaction were investigated and optimized,and different reaction conditions were studied.It was revealed that the best yields were obtained when the molar ratio of arylamine,sodium hyposulfite,sodium bicarbonate and heptafluoroisopropyl iodide was 1.2,phase transfer catalyst and arylamine was 0.1,and reaction temperature was 10~20 ℃. |
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| Keywords: | heptafluoroisopropyl 2-ethylaniline heptafluoroisopropyl iodide 2-ethyl-4-heptafluoroisopropylaniline |
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