| 间苯三酚乙酰基衍生物合成及生物活性研究 |
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| 引用本文： | 陈贯虹,孔学,高永超,王加宁,迟建国,邱维忠.间苯三酚乙酰基衍生物合成及生物活性研究[J].广州化工,2011,39(17):32-34. |
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| 作者姓名： | 陈贯虹 孔学 高永超 王加宁 迟建国 邱维忠 |
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| 作者单位： | 山东省科学院生物研究所,山东济南,250014 |
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| 基金项目： | 国家“十二五”科技支撑计划项目 以天然产物为母体的绿色农药研究，山东省科技发展计划项目 以吡喃酮与辣椒碱为母体的绿色农药研究 |
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| 摘 要： | 以2,4-二乙酰基间苯三酚为基础,通过改变一个酰基碳链的长度,合成了三个间苯三酚乙酰基衍生物,目标化合物经LC-MS进行了确证,室内生测试验结果表明,2-乙酰基-4-丙酰基间苯三酚与2-乙酰基-4-丁酰基间苯三酚对立枯丝核菌、禾谷丝核菌、灰葡萄孢具有明显的抑制作用。
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| 关 键 词： | 间苯三酚 合成 酰化 生物活性 |
Study on the Synthesis and Biological Activity of Phloroglucinol C-acetylated Derivatives |
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| CHEN Guan-hong,KONG Xue,GAO Yong-chao,WANG Jia-ning,CHI Jian-guo,QIU Wei-zhong.Study on the Synthesis and Biological Activity of Phloroglucinol C-acetylated Derivatives[J].GuangZhou Chemical Industry and Technology,2011,39(17):32-34. |
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| Authors: | CHEN Guan-hong KONG Xue GAO Yong-chao WANG Jia-ning CHI Jian-guo QIU Wei-zhong |
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| Affiliation: | 1,2(1 Biology Institute of Shandong Academy of Sciences,Shandong Jinan 250014;2 Key Laboratory for Applied Microbiology of Shandong Province,Shandong Jinan 250014,China) |
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| Abstract: | Three phloroglucinol acetylated derivatives were synthesized with 2,4-diacetylphloroglucinol as the basis structure.All the compounds synthesized were confirmed by LC-MS.The results of preliminary bioassay showed that two compounds of 2-acetyl-4-propionylphloroglucinol and 2-acetyl-4-butyrylphloroglucinol had obvious inhibitive effect on Rhizoctonia solani,Rhizoctonia cerealis,and Botrytis cinerea. |
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| Keywords: | phloroglucinol acetylation synthesis biological activity |
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