| 聚乙二醇改性水溶性壳聚糖对蛋白药物的释放作用 |
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| 引用本文： | 王春,扶雄,杨连生.聚乙二醇改性水溶性壳聚糖对蛋白药物的释放作用[J].现代食品科技,2011,27(8):885-886,911. |
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| 作者姓名： | 王春 扶雄 杨连生 |
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| 作者单位： | 1. 广东石油化工学院化学与生命科学学院,广东茂名,525000
2. 华南理工大学轻工与食品学院,广东广州,510640 |
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| 摘 要： | 本文采用离子交联的方法,研究制备了聚乙二醇( PEG)修饰的水溶性壳聚糖(WSC)药物载体.以牛血清蛋白(BSA)作为模型蛋白药物,对纳米粒子的物理化学性质作了初步检测.由于分子间的竞争作用,PEG的修饰在一定程度上降低了WSC纳米粒子的药物负载能力.体外释放实验表明PEG修饰的纳米粒子在一定程度上加快了BSA的释放,...
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| 关 键 词： | 水溶性壳聚糖 聚乙二醇 纳米粒子 牛血清蛋白 蛋白质释放 |
PEG Modified Water-soluble Chitosan Nanoparticles for Drug Delivery |
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| WANG Chun,FU Xiong,YANG Lian-sheng.PEG Modified Water-soluble Chitosan Nanoparticles for Drug Delivery[J].Modern Food Science & Technology,2011,27(8):885-886,911. |
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| Authors: | WANG Chun FU Xiong YANG Lian-sheng |
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| Affiliation: | 1.Chemistry and Life Science College,Guangdong University of Petrochemical Technology,Maoming 525000,China)(2.College of Light Industry and Food Sciences,South China University of Technology,Guangzhou 510640,China) |
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| Abstract: | PEG modified WSC nanoparticles were prepared based on ionic gelation and the capability of PEG modified water-soluble chitosan(WSC) was used as carriers to load and delivery drug.As a model protein drug,bovine serum albumin(BSA) was incorporated into the nanoparticles.Physicochemical of characterizations of WSC nanoparticles was determined preliminarily.PEG introduction might decrease loading capability of nanoparticles due to the competition effect between BSA and PEG.And in vitro release demonstrated that PEG modification could increase release of loading protein drug but the nanoparticles displayed a good release performance still. |
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| Keywords: | water-soluble chitosan(WSC) PEG nanoparticle BSA protein delivery |
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