罗红霉素电化学行为的线性扫描极谱法研究

应用线性扫描极谱法研究罗红霉素的电化学行为。在0．1mol·L^-1 Na2HPO4-KH2PO4缓冲溶液（pH=6．90）中，罗红霉素于-1．48V（vs．SCE）处产生一灵敏的吸附波，其一次微分线性扫描峰电流与罗红霉素浓度呈良好的线性关系，质量浓度范围1．6—200．0mg·L^-1，相关系数r=0．9972（n=10），检出限为0．6mg·L^-1。以80．0mg·L^-1罗红霉素溶液作6次平行试验，RSD为0．42％，回收率在98．9％-108．2％之间。罗红霉素的此电化学特性可用于其胶囊含量测定。

Study on Roxithromycin Capsules Electrochemical Behavior by the Linear Scanning Polarographic Method

The electrochemical behavior of Roxithromycin Capsules was studied by linear scanning polarographic method. In 0.2 mol·L^-1 phosphate buffer solution（pH6.90）, a sensitive reductive wave of Roxithromycin Capsules appeared at- 1.48V（vs. SCE）. The linear relationship between the peak current and the Roxithromycin Capsules concentration in the range of 1.6- 200.0 mg·L^-1（ r = 0.995 8, n = 10）were observed. The detection limit of this method was 0.8 mg·L^-1. RSD was 0.73 %. From the data of 6 independent determinations at the concentration level of 80.0 mg·L^-1, the recovery ratio was 97.7 % - 109.2 %. This Roxithromycin Capsules＇s electrochemical characteristic propertymay could be used to determine the contents of tablets.