Attachment and growth of human rotaviruses RV-3 and S12/85 in Caco-2 cells depend on VP4 |
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| Authors: | CD Kirkwood RF Bishop BS Coulson |
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| Affiliation: | Department of Gastroenterology and Clinical Nutrition, Royal Children's Hospital, Parkville 3052, Victoria, Australia. |
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| Abstract: | Studies with human neonatal rotaviruses RV-3 and S12/85 and their reassortants showed that VP4 is a determinant of rotavirus attachment to and growth in Caco-2 cells. The binding of these viruses to MA104 and Caco-2 cells correlated with their growth ability. Virus sensitivity to trypsin and the VP4 fusion region may be implicated in these processes. |
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