Changes in fatty acid composition of plasma and oviduct lipids during sexual maturation of Japanese quail |
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Authors: | Jean François Pageaux Catherine Joulain Jean Michel Fayard Michel Lagarde Christian Laugier |
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Affiliation: | (1) Physiology Laboratory, INSERM U.352, Institut National des Sciences Appliquées, 69621 Villeurbanne Cedex, France;(2) Biochemistry Laboratory, INSERM U.352, Bat. 406, Institut National des Sciences Appliquées, 20 av. A. Einstein, 69621 Villeurbanne Cedex, France |
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Abstract: | The fatty acid (FA) compositions of plasma and oviduct phospholipids (PL) and triglycerides (TG) were studied throughout the
natural sexual development of the Japanese quail. In the oviduct, PL concentration increased rapidly during the period of
active oviduct cell proliferation and then remained at a constant level during the phase of cellular hypertrophy. Oviduct
and plasma TG concentrations were 2- and 10-fold higher, respectively, in fully developed animals than in immature ones. During
natural sexual maturation of the quail, the FA compositions of PL and TG were markedly modified both in plasma and in oviduct.
These qualitative changes occurred predominantly during the period of intense cellular proliferation of oviduct cells, and
also were observed in immature animals injected with physiological doses of estradiol. In oviduct PL, the proportions of 20∶4n−6
and 22∶4n−6 decreased significantly (from 20 to 10% and 3.5 to 0.7%, respectively) whereas those of 18∶2n−6 increased (from
8.5 to 21%). In contrast, the plasma PL proportions of 20∶4n−6, 22∶4n−6 and 18∶2n−6 were decreased significantly and the percentage
of 18∶1n−9 doubled, suggesting that the oviduct is able to utilize certain plasma FA to a greater extent than others. Changes
in plasma and oviduct lipid composition occurring in the quail during sexual development may be attributed to estradiol, which
stimulates hepatic Δ9 desaturase and inhibits the oviduct Δ6 desaturase. The changes in FA composition observed in oviduct
phospholipids are discussed in relation to eicosanoid production and cellular proliferation. |
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