Chemical alignment of DNA origami to block copolymer patterned arrays of 5 nm gold nanoparticles |
| |
Authors: | Pearson Anthony C Pound Elisabeth Woolley Adam T Linford Matthew R Harb John N Davis Robert C |
| |
Affiliation: | Department of Physics and Astronomy, Brigham Young University, Provo, Utah 84602, United States. |
| |
Abstract: | We have used block copolymer patterned arrays of 5 nm gold nanoparticles (AuNPs) for chemically aligned surface attachment of DNA origami. Addition of single-stranded DNA-thiol to AuNPs allowed a base paired attachment of sticky end modified DNA origami. Results indicate a stable, selective attachment between the DNA origami and ssDNA modified AuNPs. Yield data showed 74% of AuNP binding sites forming an attachment with a DNA origami rectangle, and control surfaces showed less than 0.5% nonspecific adsorption. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|