Discriminating schizophrenia and schizo-obsessive disorder: a structural MRI study combining VBM and machine learning methods |
| |
Authors: | Tas Cumhur Mogulkoc Hazal Eryilmaz Gul Gogcegoz-Gul Is?l Erguzel Turker Tekin Metin Bar?? Tarhan Nevzat K |
| |
Affiliation: | 1.Department of Psychology, Uskudar University, Altunizade Mah. Haluk Turksoy Sk. No:14, Uskudar, 34662, Istanbul, Turkey ;2.Division of Cognitive Neuropsychiatry and Psychiatric Preventative Medicine, Ruhr University, Bochum, NRW, Germany ;3.NP?stanbul Neuropsychiatry Hospital, Istanbul, Turkey ;4.Department of Computer Engineering, Uskudar University, Istanbul, Turkey ; |
| |
Abstract: | Schizo-obsessive disorder is characterized by the clinical syndrome in which comorbid obsessive–compulsive disorder accompanies schizophrenia. A substantial number of studies have investigated the neuropsychological and clinical differences between schizophrenia and schizo-obsessive disorder. However, the neurostructural differences between these two groups have not been adequately investigated. The aim of this study was to explore gray matter differences between schizophrenia and schizo-obsessive patients using voxel-based morphometry and support vector machines combined with feature selection algorithm. Twenty-three schizophrenia and 23 schizo-obsessive patients matched by age, gender and handedness were recruited. Clinical assessments were completed in addition to high-resolution structural MRI scanning. Group differences were investigated using contrast maps, and significant regions were subjected to a feature selection and support vector machine hybrid model. In addition, voxel-of-interest values for the commonly shared brain areas between schizophrenia and OCD reported in previous meta-analyses were also used as inputs in this step. The results showed that schizo-obsessive patients had greater gray matter densities in paracentral areas (including supplementary motor area) and middle cingulate gyrus than schizophrenia patients. These brain areas together with the fronto-subcortical areas could successfully discriminate two groups with an accuracy of 78.26 %. Our results provide the first neuroanatomical evidence that schizo-obsessive disorder and schizophrenia may be two distinct clinical entities. Based on these findings, considering schizo-obsessive disorder as a subtype of schizophrenia is discernible. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|