“In Vitro” - “In Vivo” Correlations of Eight Nitrofurantion Tablet Formulations: Effect of Various Technological Factors |
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| Authors: | A Cheiro L J Vila-Jato R Martinez-Pacheco B Seijo T Ramos |
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| Abstract: | The bioavailability of eight nitrofurantoin tablet formulations differing in technological respects has been evaluated and correlated with de dissolution curves obtained using USP XXI Ed methods I and II. Method I was found incapable of predicting bioavailability of formulations when Carbopol 934 is used as binder. The influence of the technological factors varied is discussed. |
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