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A case of a single molluscum contagiosum occurring on the surface of a preexisting soft fibroma in an adult patient is reported. The most common clinical form of this viral lesion is multiple grouping papules with a central umbilication and its histologic feature is characteristic. Previous cases of mollusca combining with other lesions have been rarely described. Our lesion was probably due to its localization on the soft fibroma, whose exophytic growing represented a favoring factor for trauma and the consequent occurrence of the viral disease.