| 水合肼还原法合成4-氨基-1-甲基-3-正丙基吡唑-5-甲酰胺 |
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| 引用本文： | 徐宝峰,彭安顺.水合肼还原法合成4-氨基-1-甲基-3-正丙基吡唑-5-甲酰胺[J].化学工程师,2002(3):1-2. |
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| 作者姓名： | 徐宝峰 彭安顺 |
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| 作者单位： | 临沂师范学院化学与环境科学系,山东,276005 |
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| 摘 要： | 以1－甲基－4－硝基－3－正丙基吡唑－5－甲酰胺为原料，采用水合肼－三氯化铁－活性炭体系，合成了4－氨基－1－甲基－3－正丙基吡唑－5－甲酰，研究结果表明，水合肼还原具有操作简单，反应条件温和，成本低，收率高的特点，宜于工业化生产。
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| 关 键 词： | 还原法 4－氯基－1－甲基－3－正丙基吡唑－5－甲酰胺 合成 水合肼 PDE5抑制剂 亚地那非 药物中间体 |
| 文章编号： | 1002-1124(2002)03-0001-02 |
| 修稿时间： | 2001年11月9日 |
Synthesis of 4- Amino- 1 - Methyl- 3 - n - Propylpyrazele- 5 - Carboxamide with Hydrazine Hydrate Reduction |
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| Xu Baofeng Peng Anshun.Synthesis of 4- Amino- 1 - Methyl- 3 - n - Propylpyrazele- 5 - Carboxamide with Hydrazine Hydrate Reduction[J].Chemical Engineer,2002(3):1-2. |
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| Authors: | Xu Baofeng Peng Anshun |
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| Abstract: | The synthesis of 4-amino-1-methyl-3- n -propylpyrazole-5-carboxamide from 1-methyl-4-nitro-3- n -propylprazole-5-carboxamide was improved. The hydrazine bydrate-iron trichloride-activated carbon system has been utilized as reductant. The experimental results show hydrazine hydrate reducion that it was simple, mild and inexpnsive. The yield was higher and more suitable for industrial prodution. |
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| Keywords: | Amino-1-Methyl-3- n -Propylpyrazole-5-Carboxamide Sythesis Hydrazine Hydrate |
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