Colloidal systems made of biotransesterified α, β and γ cyclodextrins grafted with C10 alkyl chains |
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Authors: | A. Gèze L. Choisnard J.-L. Putaux D. Wouessidjewe |
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Affiliation: | 1. Université de Grenoble CNRS UMR 5063, DPM-Pharmacotechnie, Institut de Chimie Moléculaire de Grenoble (ICMG) FR-2607, UFR de Pharmacie, BP 53, F-38041, Cedex 9, France;2. Centre de Recherche sur les Macromolécules Végétales (CERMAV-CNRS), BP 53, F-38041 Grenoble Cedex 9, France |
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Abstract: | Alpha (α), beta (β) and gamma (γ) fatty ester cyclodextrins with C10 alkyl chains (CD-C10) on the secondary face were synthesized using an enzymatic pathway involving thermolysin as a biocatalyser. Depending on the formulation, these new cyclodextrin derivatives self-assembled and formed nanostructures presenting the ability to entrap diazepam, a lipophilic model drug. The loaded nanoparticles were tested for in vitro release of the drug molecule. Biphasic release profiles were observed with a pronounced delayed release in the case of γCD-C10 nanoparticles, associated to a low initial burst effect. These results are encouraging and may constitute the basis for designing novel multifunctional nanoscale systems made up with versatile cyclodextrin derivatives. |
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