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LHRH-functionalized superparamagnetic iron oxide nanoparticles for breast cancer targeting and contrast enhancement in MRI |
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| Authors: | J. Meng J. Fan G. Galiana R.T. Branca P.L. Clasen S. Ma J. Zhou C. Leuschner C.S.S.R. Kumar J. Hormes T. Otiti A.C. Beye M.P. Harmer C.J. Kiely W. Warren M.P. Haataja W.O. Soboyejo |
| Affiliation: | 1. Princeton Institute of Science and Technology of Materials and the Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544, United States;2. Department of Chemistry, Princeton University, Princeton, NJ 08544, United States;3. Department of Chemistry, Duke University, Durham, NC 27708-0354, United States;4. Center for Advanced Materials and Nanotechnology, Lehigh University, Bethlehem, PA 18015-3195, United States;5. Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, United States;6. Center for Advanced Microstructures and Devices, Louisiana State University, 6980 Jefferson Hwy, Baton Rouge, LA 70806, United States;7. Department of Physics, Makerere University, Kampala, Uganda;8. Department of Physics, Cheikh Anta Diop University, Dakar, Senegal |
| Abstract: | This paper shows that superparamagnetic iron oxide nanoparticles (SPIONs) conjugated to luteinizing hormone releasing hormone (LHRH) (LHRH–SPIONs), can be used to target breast cancer cells. They also act as contrast enhancement agents during the magnetic resonance imaging of breast cancer xenografts. A combination of transmission electron microscopy (TEM) and spectrophotometric analysis was used in our experiments, to investigate the specific accumulation of the functionalized superparamagnetic iron oxide nanoparticles (SPIONs) in cancer cells. The contrast enhancement of conventional T2 images obtained from the tumor tissue and of breast cancer xenograft bearing mice is shown to be much greater than that in saline controls, when the tissues were injected with LHRH–SPIONs. Magnetic anisotropy multi-CRAZED images of tissues extracted from mice injected with SPIONs were also found to have enhanced MRI contrast in breast cancer xenografts and metastases in the lungs. |
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