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SPECT/MRI双模态显像剂SPION-DMSA-~(99)Tc~m的制备及其性质研究
引用本文:王晓,崔海平,史旭东,梁积新,孙钰林,申一鸣,沈浪涛.SPECT/MRI双模态显像剂SPION-DMSA-~(99)Tc~m的制备及其性质研究[J].原子能科学技术,2015,49(9):1557-1564.
作者姓名:王晓  崔海平  史旭东  梁积新  孙钰林  申一鸣  沈浪涛
作者单位:1.中国原子能科学研究院 国家同位素工程技术研究中心,北京102413;2.原子高科股份有限公司,北京102413
摘    要:为制备纳米材料SPION-DMSA及其标记物SPION-DMSA-99Tcm,探讨该标记物作为SPECT/MRI双模态显像剂的可能性,本工作先采用高温热解法合成了SPION,然后用DMSA包覆获得SPIONDMSA并进行各种表征。用99Tcm标记SPION-DMSA得到SPION-DMSA-99Tcm,并对该标记物进行荷U87MG人脑神经胶质瘤裸鼠的生物分布和显像研究。实验结果表明,SPION-DMSA具有超顺磁性,99Tcm标记率大于98%。SPION-DMSA-99Tcm在血液中清除较快,在肝脏中的摄取较高。SPIONDMSA-99Tcm与DMSA-99Tcm(Ⅴ)在小鼠体内的生物分布差异较大。SPION-DMSA-99Tcm在肿瘤中并没有明显的摄取。SPION-DMSA和SPION-DMSA-99Tcm的MRI和SPECT显像结果表明,SPIONDMSA和SPION-DMSA-99Tcm的肿瘤被动靶向作用有限。因此,对于荷U87MG人脑神经胶质瘤裸鼠,SPION-DMSA-99Tcm还不是一种理想的SPECT/MRI双模态显像剂。

关 键 词:超顺磁氧化铁纳米颗粒    二巯基丁二酸    99Tcm" target="_blank">99Tcm')">99Tcm    SPECT/MRI双模态显像剂

Preparation and Evaluation of SPION-DMSA-99Tcm as SPECT/MRI Dual-modal Imaging Agent
WANG Xiao,CUI Hai-ping,SHI Xu-dong,LIANG Ji-xin,SUN Yu-lin,SHEN Yi-ming,SHEN Lang-tao.Preparation and Evaluation of SPION-DMSA-99Tcm as SPECT/MRI Dual-modal Imaging Agent[J].Atomic Energy Science and Technology,2015,49(9):1557-1564.
Authors:WANG Xiao  CUI Hai-ping  SHI Xu-dong  LIANG Ji-xin  SUN Yu-lin  SHEN Yi-ming  SHEN Lang-tao
Affiliation:1.National Isotope Center of Engineering and Technology, China Institute of Atomic Energy, Beijing 102413, China; 2.Atom Hi-Tech Co., Ltd., Beijing 102413, China
Abstract:Nanoparticle SPION-DMSA and its radiolabeled SPION-DMSA-99Tcm were prepared in order to investigate the possibility of SPION-DMSA-99Tcm as a SPECT/MRI dual-modal imaging agent. SPION was synthesized by a hydrothermal process, and then coated with DMSA to afford SPION-DMSA. SPION-DMSA was characterized by means of various methods. SPION-DMSA-99Tcm was obtained by labeling with 99Tcm. The data of biodistribution and the SPECT and MRI images were acquired after injecting SPION-DMSA-99Tcm into the nude mice bearing U87MG human glioma in various intervals. The results show that SPION-DMSA exhibits super-magnetic properties. The labeling yield of SPION-DMSA with 99Tcm was more than 98%. SPION-DMSA-99Tcm is cleared from the blood quickly and has higher uptake in the liver. There was a big difference of biodistributions between SPION-DMSA-99Tcm and DMSA-99Tcm (Ⅴ) in the nude mice. The uptake of SPION-DMSA 99Tcm in tumor is not obvious. The results of imaging made by MRI and SPECT using SPION-DMSA and SPION-DMSA-99Tcm respectively show that the tumor passive targeting of SPION-DMSA and SPION-DMSA-99Tcm is limited. Therefore, SPION-DMSA-99Tcm is not an ideal SPECT/MRI dual modal imaging agent for the nude mice bearing U87MG human glioma.
Keywords:super-magnetic iron oxide nanoparticle  DMSA  99Tcm  SPECT/MRI dual-modal imaging agent
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