Metabolic transformation of intracraneally injected [1-14C]linoleic and [1-14C]α-linolenic acids in malnourished developing rats |
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Authors: | Maria Elena De Tomas Osvaldo Mercuri Cristina Serres |
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Affiliation: | (1) Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP), Facultad de Ciencias Médicas, Calle 60 y 120, 1900 La Plata, Argentina;(2) Present address: Carrera del Investigador científico of the Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina |
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Abstract: | The effect of a low protein diet during pregnancy and lactation on the fatty acid composition of phosphatidylcholine (PC)
and phosphatidylethanolamine (PE) from brains of ten-day-old rats was studied. The results indicated that partial deprivation
of protein during early development was associated with an increase in the fatty acids of the n−9 family in PC. The fatty
acids of the linoleic acid series decreased in PE but were not modified in PC. These minor changes did not affect the double
bond index values either in PC or in PE. The effect of protein depletion on thein vivo metabolic transformation of intracraneally injected 1-14C]linoleic and 1-14C]α-linolenic acids was also studied. The percentage distribution of the labeled precursors and their derivatives among PC
and PE differed from that of mass distribution. These results indicate that the direct uptake of polyunsaturated fatty acids
from the blood and/or the low turnover rate of these acids incorporated into PC and PE might be involved in maintaining the
fatty acid pattern of these brain lipids. |
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