Dipyridamole recognition and controlled release by uniformly sized molecularly imprinted nanospheres |
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Authors: | Mehdi Esfandyari-Manesh Mehran Javanbakht Fatemeh Atyabi Ali Mohammadi Somayeh Mohammadi Behrouz Akbari-Adergani Rassoul Dinarvand |
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Affiliation: | 1. Department of Chemistry, Amirkabir University of Technology, Tehran, Iran;2. Nano Science and Technology Research Center, Amirkabir University of Technology, Tehran, Iran;3. Nanotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran;4. Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran;5. Food and Drug Laboratory Research Center, Food and Drug Department, Ministry of Health and Medical Education, Tehran, Iran |
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Abstract: | We used novel synthetic conditions of precipitation polymerization to obtain uniformly sized molecularly imprinted nanospheres of dipyridamole for application in the design of new drug delivery systems. In addition, the morphology, drug release, and binding properties of molecularly imprinted polymers (MIPs) were studied, and the effects of morphology on other properties were investigated. The MIPs prepared by acetonitrile/chloroform (19:1, v/v) were uniformly sized nanospheres with an average mean diameter of approximately 88 nm at a wetted state, 50 nm at a dry state, and a polydispersity index of 0.062. The imprinted nanospheres showed excellent binding properties and had 62.7% of template binding compared with 17.1% of its blank polymer. The imprinted nanospheres with 67.5 (mg template/of polymer) of binding capacity had better imprinting efficiency than the 50.5% of binding capacity shown by irregularly shaped MIP particles that were prepared by chloroform. The molecular binding abilities of imprinted nanospheres in human serum were evaluated by HPLC analysis (binding about 77% of dipyridamole). Results from release experiments of MIPs showed a very slow, controlled, and satisfactory release of dipyridamole. The loaded drug was released up to 99% in 17 days for nanospheres and 22 days for irregularly shaped particles. |
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