GOX-functionalized nanodiamond films for electrochemical biosensor |
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| Authors: | Pedro Villalba Manoj K. Ram Humberto Gomez Amrita Kumar Venkat Bhethanabotla Ashok Kumar |
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| Affiliation: | 1. Department of Mechanical Engineering, University of South Florida, 4202 E Fowler Avenue, Tampa, FL, 33620-5350, United States;2. Nanotechnology Research and Education Center, University of South Florida, United States;3. Department of Chemical and Biomedical Engineering, University of South Florida, United States;4. Departamento de Medicina, Universidad del Norte, Barranquilla, Colombia;5. Department of Physiology, Emory University. Atlanta GA, United States |
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| Abstract: | The importance of nanodiamond in biological and technological applications has been recognized recently, and applied in drug delivery, biochip, sensors and biosensors. Under this investigation, nanodiamond (ND) and nitrogen doped nanodiamond (NND) were deposited on n-type silicon films, and later functionalized with enzyme Glucose oxidase (GOX). The GOX functionalized doped and undoped ND films were characterized using combination of several techniques; i.e. FTIR spectroscopy, Raman spectroscopy, atomic force microscopy (AFM) and electrochemical techniques. ND/GOX and NND/GOX thin films on n-type silicon have been found to provide sensitive glucose sensor. GOX has been chosen as a model enzyme system to functionalize with ND at molecular level to understand the glucose biosensor. |
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