Antimicrobial activity and safety of use of Enterococcus faecium PC4.1 isolated from Mongol yogurt |
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| Authors: | Imen Hadji-Sfaxi Shady El-Ghaish Aynur Ahmadova Batjargal Batdorj Gwenaëlle Le Blay-Laliberté Georges Barbier Thomas Haertlé Jean-Marc Chobert |
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| Affiliation: | 1. Department of Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea;2. High-Enthalpy Plasma Research Center, Chonbuk National University, Republic of Korea;3. Division of Marine Environment & Bioscience, Korea Maritime University, Busan, Republic of Korea;4. Biochip Research Center and Inflammatory Disease Research Center, Hoseo University, 165, Sechul-ri, Baebang-myun, Asan, Chungnam 336-795, Republic of Korea;5. Regional Innovation Center and Inflammatory Disease Research Center, Hoseo University, 165, Sechul-ri, Baebang-myun, Asan, Chungnam 336-795, Republic of Korea;6. Oriental Bio-herb Research Institute, Kangwon National University, Chuncheon 200-701, Republic of Korea;7. School of Biomedical Sciences, Charles Sturt University, Bathurst, NSW 2795, Australia |
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| Abstract: | Screening of lactic acid bacteria strains isolated from Mongolian yogurt (Tarag) led to the isolation of Enterococcus faecium PC4.1 with a bacteriocin-like activity against Listeria genus and fungi. The antimicrobial substances in cell free supernatant were sensitive to proteolytic enzymes, while neither acidic conditions nor high temperature affected their activities. These antimicrobial substances were active after storage at 4 °C, ?20 °C and ?80 °C for over one month. The mode of action was determined as bactericidal. In the aim of further use of E. faecium PC4.1 as a biopreservative, the isolate was tested for resistance against antibiotics and for harboring virulence determinants. E. faecium PC4.1 was characterized as free from virulence factors, has low resistance to gentamicin and ampicillin but is susceptible to vancomycin. |
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