Madelung disease: distribution of cervical fat and preoperative findings at sonography, MR, and CT |
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Authors: | AT Ahuja AD King ES Chan J Kew WW Lam PM Sun W King C Metreweli |
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Affiliation: | Institut de Biologie de Lille-Institut Pasteur de Lille-URA CNRS 1309, France. |
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Abstract: | A simplified approach to the synthesis of 2-polyamine linked-monoindolylmaleimides has been achieved, leading to a new series of trypanothione reductase inhibitors. The conditions of access to N,2-bis(polyamine)-3-monoindolylmaleimides and N,N'-bis(monoindolylmaleimide) polyamines are described. Measured inhibitory activities towards trypanothione reductase from Tryanosoma cruzi show the importance of both aromatic moieties and polyamine chains for trypanothione reductase recognition. |
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