| 醇和小分子有机物二元双水相体系萃取盐酸多西环素 |
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| 引用本文： | 关卫省,邓江华,韩娟.醇和小分子有机物二元双水相体系萃取盐酸多西环素[J].应用化工,2012,41(6):992-995,999. |
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| 作者姓名： | 关卫省 邓江华 韩娟 |
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| 作者单位： | 1. 长安大学环境科学与工程学院,陕西西安,710064
2. 江苏大学化学化工学院,江苏镇江,212013 |
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| 基金项目： | 中央高校基本科研业务费专项资金基金资助项目 |
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| 摘 要： | 基于小分子醇双水相体系和小分子有机物双水相体系,建立了乙醇与丙酮和(NH4)2SO4形成的二元双水相体系萃取盐酸多西环素的新方法。研究了(NH4)2SO4浓度、pH值、温度、乙醇与丙酮用量和盐酸多西环素浓度对盐酸多西环素分配行为的影响。结果表明,体系的(NH4)2SO4浓度为41%,pH值在4.5～5.0,温度25℃,且盐酸多西环素的质量浓度70 mg/L时,萃取率可达93.61%,分配系数可达83.081。
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| 关 键 词： | 盐酸多西环素 二元双水相萃取 无水乙醇 丙酮 |
Extraction of doxycycline hydrochloride using anhydrous alcohol and acetone binary aqueous two phase system |
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| GUAN Wei-sheng
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DENG Jiang-hua
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HAN Juan.Extraction of doxycycline hydrochloride using anhydrous alcohol and acetone binary aqueous two phase system[J].Applied chemical industry,2012,41(6):992-995,999. |
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| Authors: | GUAN Wei-sheng DENG Jiang-hua HAN Juan |
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| Affiliation: | 1.College of Environmental Science and Engineering,Chang’an University,Xi’an 710064,China; 2.School of Chemistry and Chemical Engineering,Jiangsu University,Zhenjiang 212013,China) |
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| Abstract: | Based on the molecular alcohol aqueous two-phase system and the small molecular organic two-phase system,the new method of using anhydrous alcohol and small molecular organic(acetone) with(NH4)2SO4 binary aqueous two phase system for extracting doxycycline hydrochloride was set up.The influence factors on partition behaviors of doxycycline hydrochloride were studied,including the concentration of(NH4)2SO4,anhydrous alcohol and acetone consumption,pH value,temperature and doxycycline hydrochloride.The results showed that when(NH4)2SO4 concentration of 41%,pH value of 4.5～5.0,and the temperature of 25 ℃,mass concentration of doxycycline hydrochloride 70 mg/L,the extraction rate up to 93.61% and 83.081,respectively. |
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| Keywords: | doxycycline hydrochloride aqueous two phase extraction anhydrous alcohol acetone |
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