| 3-甲基-5-苯基-2-(3-氟苯基)吗啉盐酸盐合成及其抗实验性抑郁活性 |
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| 引用本文： | 陈川,肖新荣,梁俊,夏岳韬,贾小鹏,陶源.3-甲基-5-苯基-2-(3-氟苯基)吗啉盐酸盐合成及其抗实验性抑郁活性[J].应用化工,2012,41(2):227-228,236. |
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| 作者姓名： | 陈川 肖新荣 梁俊 夏岳韬 贾小鹏 陶源 |
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| 作者单位： | 南华大学化学化工学院,湖南衡阳,421001 |
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| 基金项目： | 湖南省科技厅资助课题(04SK3053-3) |
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| 摘 要： | 1-(3-氟苯)-2-溴-1-丙酮在非质子极性溶剂中经胺化、环合反应,最后酸化,得到3-甲基-5-苯基-2-(3-氟基苯基)吗啉盐酸盐,总收率为70.6%。目标化合物结构经IR、1H NMR、MS测试技术确证。参照Porsolt法,使用小鼠强迫游泳药理实验模型,对所合成的化合物进行抗实验性抑郁药理活性研究。结果显示,此化合物具有良好的抗抑郁活性,值得进一步研究。
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| 关 键 词： | 苯基氨基乙醇 吗啉盐酸盐 合成 抗抑郁活性 |
Synthesis and antidepressiv.e activity of 3-methyl-5-phenyl-2-( 3-fluorophenyl ) morpholine hydrochloride |
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| CHEN Chuan
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XIAO Xin-rong
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LIANG Jun
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XIA Yue-tao
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JIA Xiao-peng
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TAO Yuan.Synthesis and antidepressiv.e activity of 3-methyl-5-phenyl-2-( 3-fluorophenyl ) morpholine hydrochloride[J].Applied chemical industry,2012,41(2):227-228,236. |
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| Authors: | CHEN Chuan XIAO Xin-rong LIANG Jun XIA Yue-tao JIA Xiao-peng TAO Yuan |
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| Affiliation: | (College of Chemistry and Chemical Engineering,University of South China,Hengyang 421001,China) |
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| Abstract: | 3-Methyl-5-phenyl-2-(3-fluorophenyl)morpholine hydrochloride was synthesized from 2-bromo-1-(3-fluorophenyl)-1-propanone via aminnation and cyclization in nonproton polar solvent,at last acidified by divergent synthetic method,with yield of 70.6%.Its structure was confirmed by IR and 1H NMR.Their antidepressant activities were tested with mice forced swimming test.The compound is worth to the further investigate in antidepressant activity. |
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| Keywords: | aminophenylalcohol arylmorpholine synthesis antidepressant activity |
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