| 巯基取代的脂肪族醛的高效合成 |
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| 引用本文： | 王宝龙,李明华,兰婷,刘鹏,王海波,张俊娜. 巯基取代的脂肪族醛的高效合成[J]. 应用化工, 2012, 41(6): 1092-1093 |
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| 作者姓名： | 王宝龙 李明华 兰婷 刘鹏 王海波 张俊娜 |
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| 作者单位： | 第四军医大学药学院化学教研室,陕西西安,710032 |
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| 摘 要： | 以溴代丁酸乙酯为原料,经过苯硫酚发生亲核取代,氢化铝锂还原,PCC氧化,以总收率87%获得最终产物,其结构经过1H NMR和MS表征。
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| 关 键 词： | 溴代丁酸乙酯 还原 PCC氧化 |
High efficient synthesis of sulfydryl substituted aliphatic aldehydes |
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| WANG Bao-long , LI Ming-hua , LAN Ting , LIU Peng , WANG Hai-bo , ZHANG Jun-na. High efficient synthesis of sulfydryl substituted aliphatic aldehydes[J]. Applied chemical industry, 2012, 41(6): 1092-1093 |
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| Authors: | WANG Bao-long LI Ming-hua LAN Ting LIU Peng WANG Hai-bo ZHANG Jun-na |
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| Affiliation: | (Department of Chemistry,School of Pharmacy,the Fourth Military Medical University,Xi’an 710032,China) |
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| Abstract: | Sulfydryl substituted aliphatic aldehyde was synthesized from 4-bromobutyric acid ethyl ester by three-steps reaction of substitution,reduction and PCC oxidation.The total yield was 87%,the structure was characterized by 1H NMR and ESI-MS. |
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| Keywords: | 4-bromobutyric acid ethyl ester reduction PCC oxidation |
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