| (E)-4-吗啉-2-丁烯酸盐酸盐的合成 |
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| 引用本文： | 景梦梦,王尧斌,雷美娟,邱方利.(E)-4-吗啉-2-丁烯酸盐酸盐的合成[J].应用化工,2012,41(2):212-213,216. |
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| 作者姓名： | 景梦梦 王尧斌 雷美娟 邱方利 |
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| 作者单位： | 台州学院医药化工系,浙江临海,317000 |
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| 基金项目： | 国家自然科学基金资助项目(21106090) |
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| 摘 要： | 以吗啉为起始原料,与溴丁烯酸甲酯反应,得到4-吗啉-2-丁烯酸甲酯,然后在二氧六环中用浓盐酸水解,得到目标产物,总收率为49.65%,产物结构经过1H NMR确证。
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| 关 键 词： | (E)-4-吗啉-2-丁烯酸盐酸盐 吗啉 4-溴丁烯酸甲酯 合成 |
Synthesis of (E)-4-morpholine-2-butenoic acid hydrochloride |
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| JING Meng-meng
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WANG Yao-bin
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LEI Mei-juan
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QIU Fang-li.Synthesis of (E)-4-morpholine-2-butenoic acid hydrochloride[J].Applied chemical industry,2012,41(2):212-213,216. |
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| Authors: | JING Meng-meng WANG Yao-bin LEI Mei-juan QIU Fang-li |
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| Affiliation: | (Department of Pharmaceutical and Chemical Engineering,Taizhou University,Linhai 317000,China) |
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| Abstract: | (E)-4-morpholine-2-butenoic acid hydrochloride was synthesized from morpholine and 4-bromo-2-butenoic acid methyl ester obtained from 4-morpholine methyl crotonate.Then it was hydrolysised by hydrochloric acid in dioxane.The overall yield of target product was 49.65%.The product was characterized by 1H NMR spectrometry. |
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| Keywords: | (E)-4-morpholine-2-butenoic acid hydrochloride morpholine 4-bromo-2-butenoic acid methyl ester synthesis |
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