Partition coefficients of ionizable compounds in o-nitrophenyl octyl ether/water measured by the potentiometric method |
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| Authors: | Liu Xiangli Bouchard Géraldine Girault Hubert H Testa Bernard Carrupt Pierre-Alain |
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| Affiliation: | Institut de Chimie Thérapeutique, Section de Pharmacie, Université de Lausanne, BEP, CH-1015 Lausanne, Switzerland. |
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| Abstract: | The objective of this study was to investigate the reliability of potentiometric measurements of partition coefficients (log P) in the o-NPOE/water system, o-nitrophenyl octyl ether being an organic solvent widely used for the voltammetric determination of the partition coefficient of ions. Three sets of ionizable model compounds were explored in this study. The results showed that the potentiometric technique gave precise and reliable log P(npoe) values in the explored range of 0.1-4.3. |
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