Ribonucleoside 3'-phosphates as pro-moieties for an orally administered drug |
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| Authors: | Michael J Palte Amy K F Davis Nicholas A McGrath Carol A Spiegel Ronald T Raines |
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| Affiliation: | Medical Scientist Training Program and Molecular & Cellular Pharmacology Graduate Training Program, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705 (USA). |
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| Abstract: | A matter of timing: Ribonucleoside 3'-phosphates are promising pro-moieties for the timed release of orally available drugs. The pro-moiety enhances the aqueous solubility of a model drug, metronidazole, and masks its activity until release by human pancreatic ribonuclease. The rate of drug release can be tuned by changing the nucleobase. |
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| Keywords: | antibiotics Bacteroides fragilis metronidazole prodrugs ribonucleases |
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