Considerations for D‐Optimal Sequential Design

Classical D‐optimal design is used to create experimental designs for situations in which an underlying system model is known or assumed known. The D‐optimal strategy can also be used to add additional experimental runs to an existing design. This paper demonstrates a study of variable choices related to sequential D‐optimal design and how those choices influence the D‐efficiency of the resulting complete design. The variables studied are total sample size, initial experimental design size, step size, whether or not to include center points in the initial design, and complexity of initial model assumption. The results indicate that increasing total sample size improves the D‐efficiency of the design, less effort should be placed in the initial design, especially when the true underlying system model isn't known, and it is better to start off with assuming a simpler model form, rather than a complex model, assuming that the experimenter can reach the true model form during the sequential experiments. Copyright © 2013 John Wiley & Sons, Ltd.