| 毛细管电泳法分取制备西酞普兰单一对映体的研究 |
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| 引用本文： | 王永乐,李爱梅,林广,等. 毛细管电泳法分取制备西酞普兰单一对映体的研究[J]. 广东化工, 2014, 0(1): 14-16 |
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| 作者姓名： | 王永乐 李爱梅 林广 等 |
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| 作者单位： | [1]东华大学化学化工与生物工程学院,上海201620 [2]柳州市公安局禁毒支队,广西柳州545000 |
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| 摘 要： | 利用磺化-β-环糊精对西酞普兰两个对映异构体的立体选择性差异,建立了基于毛细管电泳技术分取制备西酞普兰单一对映体的新方法。结果表明,实验室条件下分取制备4小时后样品瓶中的(S)-异构体和(R)-异构体分别为原来的42.7%和85.2%,二者比例由100%降低为50%。该方法有望在手性药物单一对映体的工业制备中得到广泛应用。
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| 关 键 词： | 毛细管电泳 西酞普兰 单一对映体分取制备 |
A Novel Method to Prepare Monoenantiomer of Citalopram by Capillary Electrophoresis |
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| Wang Yongle,Li Aimei,Lin Guang,Xu Zhongqi. A Novel Method to Prepare Monoenantiomer of Citalopram by Capillary Electrophoresis[J]. Guangdong Chemical Industry, 2014, 0(1): 14-16 |
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| Authors: | Wang Yongle Li Aimei Lin Guang Xu Zhongqi |
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| Affiliation: | 1. College of Chemistry, Chemical Engineering and Biotechnology Donghua University, Shanghai 201620： 2. Liuzhou City Municipal Public Security Bureau Narcotics Corps, Liuzhou 545000, China) |
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| Abstract: | A novel method to prepare monoenantiomer of citalopram by capillary electrophoresis has been developed according to the difference of recognition between sulfate-β-cyclodextrin and the enantiomers of citalopram. The results show that the quantity of （S）-enantiomer and （R）-enantiomer remained in sample vial were 42.7 % and 85.2 %, respectively, and the ratio of them decreased from 100 % to 50 % after four hours. The method may be used extensively to prepare monoenantiomer in the future. |
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| Keywords: | capillaryelectrophoresis citalopram； preparation of monoenantiomer |
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