Protein Interactome Analysis for Countering Pathogen Drug Resistance |
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Authors: | Limsoon Wong Guimei Liu |
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Affiliation: | School of Computing, National University of Singapore, 13 Computing Drive, Singapore 117417 |
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Abstract: | Drug-resistant varieties of pathogens are now a recognized global threat. Insights into the routes for drug resistance in these pathogens are critical for developing more effective antibacterial drugs. A systems-level analysis of the genes, proteins, and interactions involved is an important step to gaining such insights. This paper discusses some of the computational challenges that must be surmounted to enable such an analysis; viz., unreliability of bacterial interactome maps, paucity of bacterial intera... |
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Keywords: | protein complexes protein interactomes drug resistance infectious diseases |
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