| 复相乳化法制备聚乳酸/水杨酸钠微囊 |
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| 引用本文： | 李德玲,张青,刘入洋,刘菲. 复相乳化法制备聚乳酸/水杨酸钠微囊[J]. 化学世界, 2012, 53(9): 539-542 |
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| 作者姓名： | 李德玲 张青 刘入洋 刘菲 |
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| 作者单位： | 唐山师范学院化学系,河北唐山,063600 |
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| 基金项目： | 唐山市科技局资助项目(07160213B) |
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| 摘 要： | 以W/O/W复相乳化法,聚乳酸为壁材、水杨酸钠为芯材,制备聚乳酸/水杨酸钠微囊。聚乳酸/水杨酸钠微囊的工艺条件为:水杨酸钠溶液浓度为40 mg/mL,聚乳酸溶液浓度为25mg/mL,聚乙烯醇溶液浓度为2mg/mL,内水相水杨酸钠体积为2mL,油相聚乳酸溶液体积为10mL,外水相聚乙烯醇溶液体积为60mL,即内水相与油相比为1∶5,油相与外水相体积比为1∶6。聚乳酸/水杨酸钠微囊的包封率为75.70%。
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| 关 键 词： | 聚乳酸 水杨酸钠 包封率 载药量 |
Preparation of Poly(L-lactic acid)/Sodium Salicylate Microcapsules with Diphase Emulsion Method |
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| LI De-ling , ZHANG Qing , LIU Ru-yang , LIU Fei. Preparation of Poly(L-lactic acid)/Sodium Salicylate Microcapsules with Diphase Emulsion Method[J]. Chemical World, 2012, 53(9): 539-542 |
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| Authors: | LI De-ling ZHANG Qing LIU Ru-yang LIU Fei |
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| Affiliation: | (Department of Chemistry,Tangshan Normal College,Hebei Tangshan 063000,China) |
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| Abstract: | Poly(L-lactic acid)(PLLA)/sodium salicylate microcapsules were prepared through w/o/w diphase emulsion method,in which PLLA was used as carrier and sodium salicylate was used as drug.The optimized condition for preparation of PLLA/sodium salicylate microcapsules should be as follows: 40 mg/mL sodium salicylate,25 mg/mL PLLA,2 mg/mL poly(vinyl alcohol)(PVA),10 mL PLLA and 60 mL PVA.the volume ratio of sodium salicylate and PLA condition,encapsulation efficiency of PLLA/sodium salicylate microcapsules was up to 75.70%. |
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| Keywords: | PLLA sodium salicylate encapsulation efficiency drug content |
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