计算机模拟优化的葡萄糖传感器阵列

介绍一种可植入的葡萄糖传感器阵列的设计和计算机模拟优化。葡萄糖传感器采用固定葡萄糖氧化酶层的氧电极和氧参比电极。考虑到葡萄糖传感器的使用寿命，本设计采用氧电极阵列。用计算机对氧电极阵列的氧电极排列的间距和相互影响进行了计算机模拟优化。考虑到葡萄糖传感器在体植入环境的氧浓度较低，而葡萄糖浓度较高，所以采用特殊的膜的结构，以提高葡萄糖传感器的测量范围，并用计算机模拟优化了膜的结构尺寸。

Computational Simulation of an Implan tableEnzyme-based Glucose Sen sor Array

In this paper, the model of an implantable enzyme-based glucose sensor array is presented. An important biosensor application is the continuous monitoring blood or tissue fluid glucose concentration in people with diabetes. Our research focuses on the development of a glucose sensor based on potentiostatic oxygen electrodes and immobilized glucose oxidase for long-term application as an implant in tissues. As the sensor signal depends on many design variables, a trial-and-error approach to sensor optimization can be time-consuming. Here, the properties of an implantable glucose sensor are optimized by a systematic computational simulation approach. The electrochemical characteristics of individual glucose sensors are examined and models are proposed for the distribution of oxygen and glucose in the vicinity of individual sensors.