| 3,5-二溴-4-碘吡啶合成新方法 |
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| 引用本文： | 杨维清,陈清林,刘燮洋,付超,庞雁萍.3,5-二溴-4-碘吡啶合成新方法[J].四川轻化工学院学报,2014(4):9-11. |
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| 作者姓名： | 杨维清 陈清林 刘燮洋 付超 庞雁萍 |
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| 作者单位： | 西华大学物理与化学学院,成都610039 |
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| 基金项目： | 四川省教育厅自然科学重点基金项目（12ZA156）;西华大学重点基金项目（Z1223322） |
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| 摘 要： | 报道了3,5-二溴-4-碘吡啶的两种新合成方法.首先以4-氨基吡啶为起始原料,经过溴代、再经过重氮化反应得到中间体3,4,5-三--溴吡啶,然后以3,4,5-三溴吡啶为主要原料采用两种卤素交换反应方法得到3,5-二-溴-4-碘吡啶.最后对两种卤素交换反应方法从成本、收率等方面进行了对比,对比结果表明卤交换反应中采用乙酰氯要明显优于三甲基氯硅烷.
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| 关 键 词： | 3 5-二溴-4-碘吡啶 3 4 5-三溴吡啶 4-氨基吡啶 合成 |
New Synthesis Methods of 3,5-dibromo-4-iodopyridine |
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| YANG Weiqing,CHEN Qinglin,LIU Xieyang,FU Chao,PANG Yanping.New Synthesis Methods of 3,5-dibromo-4-iodopyridine[J].Journal of Sichuan Institute of Light Industry and Chemical Technology,2014(4):9-11. |
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| Authors: | YANG Weiqing CHEN Qinglin LIU Xieyang FU Chao PANG Yanping |
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| Affiliation: | (School of Physics and Chemistry, Xihua University, Chengdu 610039, China) |
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| Abstract: | Two new methods are proposed in the paper for the synthesis of 3,5-dibromo-4-iodopyridine. First, 3,4,5- tribromopyridine was synthesized from pyridin-4-amine by the reaction of bromination and diazotization. Then, 3,5-dibromo- 4-iodopyridine was synthesized from the main starting material of 3,4,5-tribromopyridine by the halogen exchange reaction . When the two methods were compared in eost and yield, the results showed that the halogen exchange method with acetyl chloride was better than that of chlorotrimethylsilane. |
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| Keywords: | 3 5-dibromo-4-iodopyridine 3 4 5-tribromopyridine pyridin-4-amine synthesis |
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