| 2-氯甲基-4-乙氧基吡啶盐酸盐的合成 |
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| 引用本文： | 任旭红,王庆河,邓明. 2-氯甲基-4-乙氧基吡啶盐酸盐的合成[J]. 精细化工中间体, 2007, 37(5): 27-28,36 |
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| 作者姓名： | 任旭红 王庆河 邓明 |
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| 作者单位： | 1. 沈阳药科大学,制药工程学院,辽宁,沈阳,110016
2. 东北制药集团有限责任公司,辽宁,沈阳,110026 |
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| 摘 要： | 以2-甲基吡啶为起始原料,经N-氧化、硝化、乙氧基取代、酰化、水解、卤代等步骤,合成了2-氯甲基-4-乙氧基吡啶盐酸盐1,5步总收率为20%。
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| 关 键 词： | 2-氯甲基-4-乙氧基吡啶盐酸盐 中间体 合成 |
| 文章编号： | 1009-9212（2007）05-0027-02 |
| 修稿时间： | 2007-08-10 |
Synthesis of 2-Chloromethyl -4-ethoxylpyridine Hydrochloride |
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| REN Xu-hong,WANG Qing-he,DENG Ming. Synthesis of 2-Chloromethyl -4-ethoxylpyridine Hydrochloride[J]. Fine Chemical Intermediates, 2007, 37(5): 27-28,36 |
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| Authors: | REN Xu-hong WANG Qing-he DENG Ming |
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| Affiliation: | 1.School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China; 2.Northeast Pharmaceutical Group, Shenyang 110026, China |
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| Abstract: | 2-Chloromethyl-4-ethoxylpyridine hydrochloride1 was synthesized starting from 2-methylpyridine through N-oxidation,nitration,ethoxylation,acylation,hydrolysis and halogenation to give 2-hydroxymethyl-4-ethoxylpyridine and was chlorinated by sulforous oxychloride and followed by salf formation which an overall yield of 20%,indicating that the method was suitable to industrialization because of simple operation,available raw materials and low cost. |
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| Keywords: | 2-chloromethyl -4-ethyloxy pyridine hydrochloride intermediate synthesis |
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