| 在相转移催化条件下合成4-(N-异丙氨基)-苯甲酸的研究 |
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| 引用本文： | 黄祖良,韦柳斌,韦国锋,程金生. 在相转移催化条件下合成4-(N-异丙氨基)-苯甲酸的研究[J]. 化学世界, 2009, 50(5) |
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| 作者姓名： | 黄祖良 韦柳斌 韦国锋 程金生 |
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| 作者单位： | 右江民族医学院化学教研室,广西,百色,533000 |
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| 摘 要： | 在相转移催化条件下对4-(N-异丙氨基)-苯甲酸进行了合成,具体的合成条件为:相转移催化剂为十六烷基三甲基溴化铵(HDTMA),用量为m(HDTMA)∶m(2-溴丙烷)=0.04~0.06。反应温度为60~62℃,加热回流4 h直至下层的2-溴丙烷基本消失,冷却,得白色固体,产率为71.1%。
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| 关 键 词： | 相转移催化剂 对氨基苯甲酸 2-溴丙烷 4-(N-异丙氨基)-苯甲酸 烷基化反应 |
Study on the Synthesis of 4-(N-Isopropyl amino)-benzoic Acid by Phase Transfer Catalysis |
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| HUANG Zu-liang,WEI Liu-bin,WEI Guo-feng,CHENG Jin-sheng. Study on the Synthesis of 4-(N-Isopropyl amino)-benzoic Acid by Phase Transfer Catalysis[J]. Chemical World, 2009, 50(5) |
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| Authors: | HUANG Zu-liang WEI Liu-bin WEI Guo-feng CHENG Jin-sheng |
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| Affiliation: | Department of Chemistry;Youjiang Medical College for Nationalities;Guangxi Baise 533000;China |
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| Abstract: | 4-(N-isopropyl amino)-benzoic acid was synthesized from p-amino benzoic acid by alkylation reaction.A quaternary ammonium salt is used as the solvent in the phase transfer catalyzed reaction.The reaction was run under 60~62 ℃ and in a reflux state for 4 h.A white solid was obtained,and the yield reached 71.1%. |
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| Keywords: | phase-transfer catalyst p-amino benzoic acid 2-bromopropane 4-(N-isopropylamino)-benzoic acid alkylation reaction |
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