| 美洛昔康PLA缓释微球的制备及性能研究 |
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| 引用本文： | 可方远,郑婷,张月红,尚青.美洛昔康PLA缓释微球的制备及性能研究[J].现代化工,2011,31(Z1):232-235. |
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| 作者姓名： | 可方远 郑婷 张月红 尚青 |
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| 作者单位： | 河北科技大学化学与制药工程学院,河北石家庄,050018 |
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| 摘 要： | 以生物可降解材料聚乳酸(PLA)作为载体,聚乙烯醇为分散剂,二氯甲烷为溶剂,采用乳化-溶剂挥发法制备美洛昔康(Meloxicam)聚乳酸缓释微球。用生物显微镜和扫描电子显微镜观察微球形态,用傅里叶红外光谱仪检测美洛昔康是否已存在于微球中,用紫外-可见分光光度计测定了微球的包封率、载药量及其体外释药特性。结果表明:美洛昔康聚乳酸缓释微球光滑圆整,聚乳酸和美洛昔康能够有机地结合为一体,微球载药量为12.72%,包封率为89.04%,美洛昔康/PLA微球体外释放80 h后累积释药率达70%以上,具有显著的缓释作用。
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| 关 键 词： | 美洛昔康 溶剂挥发法 聚乳酸 缓释微球 |
Preparation and performance of meloxicam loaded PLA sustained-release microspheres |
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| KE Fang-yuan,ZHENG Ting,ZHANG Yue-hong,SHANG Qing.Preparation and performance of meloxicam loaded PLA sustained-release microspheres[J].Modern Chemical Industry,2011,31(Z1):232-235. |
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| Authors: | KE Fang-yuan ZHENG Ting ZHANG Yue-hong SHANG Qing |
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| Affiliation: | KE Fang-yuan,ZHENG Ting,ZHANG Yue-hong,SHANG Qing(College of Chemistry and Pharmaceutics Engineering,Hebei University of Science and Technology,Shijiazhuang 050018,China) |
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| Abstract: | The meloxicam/PLA(polylactic acid) microspheres are prepared by the solvent evaporation method,choosing the methylene chloride as a good solvent and the polyvinyl alcohol(PVA)as a dispersed agent,and the biodegradable material-polylactic acid(PLA) as a drug carrier.The morphology of microspheres are analyzed through biological microscope and scanning electron microscope,and the microspheres are analyzed by Fourier transform infrared spectroscopy to examine that whether the meloxicam exist in the microsphere... |
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| Keywords: | meloxicam solvent evaporation method PLA sustained-release microspheres |
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