| 5-氨基-1-羟乙基吡唑的合成及其酰化工艺改进 |
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| 引用本文： | 黄朋勉,杨春子,夏志维,帅达,徐果果,肖子丹.5-氨基-1-羟乙基吡唑的合成及其酰化工艺改进[J].现代化工,2011,31(Z1):300-302. |
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| 作者姓名： | 黄朋勉 杨春子 夏志维 帅达 徐果果 肖子丹 |
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| 作者单位： | 长沙理工大学化学与生物工程学院,湖南长沙,410114 |
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| 基金项目： | 湖南省科技攻关项目，长沙市科技局重点项目 |
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| 摘 要： | 介绍了5-氨基-1-羟乙基吡唑的合成及酰化保护其氨基和羟基的方法,分析了反应机理、影响反应的因素。合成5-氨基-1-羟乙基吡唑的纯度为95.1%,收率为70%,甲酰化反应温度为45℃,此条件下产品纯度99.5%,收率81.5%,通过工艺改进,简化了工艺,提高了收率,适合工业化生产。
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| 关 键 词： | 5-氨基-1-羟乙基吡唑 甲酰化 合成 |
Process improvement on synthesis and acidylate of 5-amino-l-hydroxyethylpyrazole |
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| HUANG Peng-mian,YANG Chun-zi,XIA Zhi-wei,SHUAI Da,XU Guo-guo,XIAO Zi-dan.Process improvement on synthesis and acidylate of 5-amino-l-hydroxyethylpyrazole[J].Modern Chemical Industry,2011,31(Z1):300-302. |
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| Authors: | HUANG Peng-mian YANG Chun-zi XIA Zhi-wei SHUAI Da XU Guo-guo XIAO Zi-dan |
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| Affiliation: | HUANG Peng-mian,YANG Chun-zi,XIA Zhi-wei,SHUAI Da,XU Guo-guo,XIAO Zi-dan(College of Chemical and Biological Engineering,Changsha University of Science and Technology,Changsha 410114,China) |
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| Abstract: | In this paper,the synthesis of 5-amino-1-hydroxyethyl pyrazole and different protection methods are introduced.It is found that the yields of 5-amino-1-hydroxyethyl is 95.1% with the purity of 70%,and the yield of formylation is 81.5%,with the purity of 99.5% at reaction temperature 45℃.With the improvement of process,the yield is improved,which is favour of industry. |
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| Keywords: | 5-amino-1-hydroxyethyl pyrazole formylation synthesis |
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