| 取代羟基查尔酮化合物的合成与表征 |
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| 引用本文： | 高复兴,薛灵芬,陈光辉,熊小琴,李在顺. 取代羟基查尔酮化合物的合成与表征[J]. 化学世界, 2012, 53(5): 294-296 |
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| 作者姓名： | 高复兴 薛灵芬 陈光辉 熊小琴 李在顺 |
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| 作者单位： | 河南信阳师范学院化学化工学院,河南信阳,464000 |
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| 基金项目： | 河南省自然科学基金(092300410032) |
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| 摘 要： | 查尔酮类化合物是合成黄酮类药物的重要中间体,而且它本身也具有广泛的药理活性。在稀碱催化下,于75～80℃反应1.5h,苯乙酮分别与水杨醛、5-氯水杨醛、5-硝基水杨醛进行交叉羟醛缩合反应,合成了其中两个鲜见文献报道的查尔酮类化合物,产物通过元素分析、IR、1 H NMR、MS进行了结构确证。
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| 关 键 词： | 取代查尔酮 羟醛缩合 合成 表征 |
Synthesis and Characterization of Substituted Hydroxylated Chalcone |
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| GAO Fu-xing , XUE Ling-fen , CHEN Guang-hui , XIONG Xiao-qin , LI Zai-shun. Synthesis and Characterization of Substituted Hydroxylated Chalcone[J]. Chemical World, 2012, 53(5): 294-296 |
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| Authors: | GAO Fu-xing XUE Ling-fen CHEN Guang-hui XIONG Xiao-qin LI Zai-shun |
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| Affiliation: | (College of Chemistry and Chemical Environment,Xinyang Normal University,Henan Xinyang 464000,China) |
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| Abstract: | Chalcone is an important intermediate for synthesizing flavones,and itself shows a wide variety of pharmaceutical activities.The cross-aldol condensation of acetophenone with salicylaldehyde and 5-chlorosalicylaldehyde and 5-nitrosalicylaldehyde respectively was catalyzed by a dilute sodium hydroxide solution at 75~80℃ in 1.5 h.Twe novel substituted chalcone compounds were synthesized,and their structures were confirmed by elemental analysis,IR,1H NMR and MS spectra. |
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| Keywords: | substituted chalcone aldol condensation synthesis characterization |
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