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| 氢化诺卜醇的合成研究 | |
| 引用本文： | 赵玲华,肖转泉,陈金珠,王宗德. 氢化诺卜醇的合成研究[J]. 化学世界, 2012, 53(3): 163-164,168,175 |
| 作者姓名： | 赵玲华 肖转泉 陈金珠 王宗德 |
| 作者单位： | 1. 江西农业大学林学院,江西南昌,330045 2. 江西师范大学化学化工学院,江西南昌,330027 3. 江西农业大学理学院,江西南昌,330045 |
| 基金项目： | 国家自然科学基金项目(30860223,31060101);教育部留学回国人员科研启动基金项目([2010]1561);江西省青年科学家(井冈之星)培养对象计划资助项目 |
| 摘 要： | 比较了由诺卜醇氢化合成氢化诺卜醇的两种方法:钠和正丁醇或异戊醇的化学还原法、镍催化的加压氢化法。气相色谱分析表明:用两种方法合成氢化诺卜醇时均有两种顺反异构体生成,且以顺式异构体为主;催化加压时,产物中的反式异构体仅占5%以下,用化学还原法时,反式异构体在产物中可达20%。从几方面考虑,合成cis-氢化诺卜醇应采用诺卜醇催化氢化法。 |
| 关 键 词： | 诺卜醇 氢化诺卜醇 化学还原 催化氢化 合成 |
A Study on Synthesis of Hydronopol |
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| ZHAO Ling-hua , XIAO Zhuan-quan , CHEN Jin-zhu , WANG Zong-de. A Study on Synthesis of Hydronopol[J]. Chemical World, 2012, 53(3): 163-164,168,175 | |
| Authors: | ZHAO Ling-hua XIAO Zhuan-quan CHEN Jin-zhu WANG Zong-de |
| Affiliation: | 1*(1.College of Forestry,Jiangxi Agricultural University.Jiangxi Nanchang 330045,China; 2.College of Chemistry,Jiangxi Normal University.Jiangxi Nanchang 330027,China; 3.College of Science,Jiangxi Agricultural University.Jiangxi Nanchang 330045,China) |
| Abstract: | Two synthetic methods of hydronopol from nopol were compared in this article.The two methods were chemical reduction with sodium and n-butanol or isoamyl alcohol,and pressure hydrogenation catalyzed by Raney Ni respectively.GC analysis showed that both methods would give cis-and trans-isomer,and the main product was cis-isomer.Less than 5% of the product of pressure hydrogenation was trans-isomer,while near 20% trans isomer was obtained in chemical reduction method.Taking all factors into consideration,pressure hydrogenation is the appropriate method to synthesize cis-hydronopol. |
| Keywords: | nopol hydronopol chemical reduction catalytic hydrogenation synthesis |
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