维生素A神经酰胺脂质体的初步研究

采用神经酰胺为类脂质材料研制维生素A脂质体，通过提高维生素A的稳定性和透皮吸收以有助于其在化妆品中的应用。筛选优化了维生素A脂质体的制备工艺，通过高效液相色谱对包封率、载药量、粒径及形态结构进行了研究。结果显示，脂质体形态较为圆整，平均粒径为O．171μm，包封率达98．5％，载药量为2．0％。神经酰胺作为类脂质材料制得的维生素A脂质体包封率高，可较好地应用于化妆品中。

Vitamin A ceramide-liposomes

Using ceramide as lipid materials, Vitamin A liposmes was prepared to improve the stability and percutaneous absorption of vitamin A to help in the application of cosmetics. The preparation of vitamin A liposome, encapsulation efficiency, loading amount, particle size and shape was studied. The liposomes were relatively and regularly spherical in shape and had an average size of 0.171 ix m .The encapsulation efficiency reached 98.5% and the loading amount reached 2.0%. Using ceramide as lipid materials, we got vitamin A liposomes with a high encapsulation efficiency. It can be effective and practicable for cosmetics.