温度响应性纳米介孔硅的制备、表征及其载药性能

以正硅酸乙酯、十六烷基三甲基溴化铵以及N-异丙基丙烯酰胺等为原料合成了一种新型的温度响应性介孔硅纳米粒,利用TEM、SEM、XRD、TG和氮气吸附脱附等温线对其结构进行了表征。结果表明:介孔硅微粒具有规则的介孔结构,温敏性物质N-异丙基丙烯酰胺成功嫁接于介孔硅表面。以红景天苷为模型药物,温度响应性介孔硅的载药率和包埋率分别为62.08μg/mg和31.04%。温度响应性介孔硅对红景天苷释放具有一定温度响应性。

Temperature-responsive mesoporous silica nanoparticles:preparation,characterization and research of ability as drug carrier

A novel temperature-responsive mesoporous silica nanoparticles （MSNs） was prepared by using of tetraethyl orthosilicate, cetyhrimethyl-ammonium bromide, and N-isopropyl acrylamide. The structure property of the material was characterized by TEM, SEM, XRD, TG and N2 absorption-desorption isotherm. It was indicated that me- soporous silica nanoparticles （MSNs） had successfully grafted temperature-sensitive N-isopropyl acrylamide （ NI- PAM） and had the properties of shape regularity and size uniformity. The paper took salidroside as the model. It was measured the loading content （LC） and entrapment efficiency （EE） on salidroside of the nanoparticles at the room temperature is 62.08 μg/mg and 31.04%. And the accumulated in vitro release percentage trend on salidroside of the nanopaticles in 42 ℃ is much more than that in 25 ℃. This novel nanopartieles might be a potential biological carrier in the future.