| 二甲亚砜和维生素E对照射小鼠脂质过氧化的影响 |
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| 引用本文： | 杜泽吉,苏燎原,孙国器. 二甲亚砜和维生素E对照射小鼠脂质过氧化的影响[J]. 辐射研究与辐射工艺学报, 1994, 0(1) |
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| 作者姓名： | 杜泽吉 苏燎原 孙国器 |
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| 作者单位： | 苏州医学院放射医学系 |
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| 摘 要： | 二甲亚砜（ＤＭＳＯ）和维生素Ｅ（ＶｉｔＥ）都是自由基清除剂，可抑制或阻断由自由基引发的脂质过氧化反应，减轻组织损伤和细胞的破坏。本研究应用荧光分光光度法，通过测定小鼠血清中脂质过氧化代谢产物丙二醛（ＭＤＡ）的含量来研究不同浓度的ＤＭＳＯ和维生素Ｅ对γ射线照射后小鼠的保护作用，以及两者联合应用的效果。结果表明：ＤＭＳＯ的保护作用优于ＶｉｔＥ，最大脂质过氧化抑制率（４．０Ｇｙ）分别为５５．１％和５３．６％，两者的最佳用量分别为１０ｍｇ／ｇ体重和０．２５ｍｇ／ｇ体重，联合用药的作用效果（最大脂质过氧化抑制率为６０．１％）大于单独使用时的效果。
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| 关 键 词： | 辐射，二甲亚砜，维生素E，脂质过氧化 |
EFFECTS OF DMSO AND VIT E ON LIPID PEROXIDATION OF IRRADIATED MICE |
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| Du Zeji, Su Liaoyuan, Sun Guoqi. EFFECTS OF DMSO AND VIT E ON LIPID PEROXIDATION OF IRRADIATED MICE[J]. Journal of Radiation Research and Radiation Processing, 1994, 0(1) |
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| Authors: | Du Zeji Su Liaoyuan Sun Guoqi |
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| Abstract: | DMSO and Vit E are scavergers of free radicals, they can supress or stop reactions of peroxidation. In this study, the fluorescence spectrophotometry was used to determine MDA levels in serum of irradiated mice, The results indicated that both DMSO and Vit E could reduce MDA levels, their suitable doses were10 mg/g body weight and 0.25 mg/g body weight respectively. The effect of DMSOwas better than that of Vit E. The best effect took place when they were used'combinatively. |
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| Keywords: | Irradiation Dimethylsulphoxide. Vit E Lipid peroxidation |
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