| 甲壳素超微粉碎辅助制备D-氨基葡萄糖盐酸盐 |
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| 引用本文： | 朱兴一,张玉燕,谢捷,王平.甲壳素超微粉碎辅助制备D-氨基葡萄糖盐酸盐[J].食品工业科技,2011(11):321-324. |
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| 作者姓名： | 朱兴一 张玉燕 谢捷 王平 |
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| 作者单位： | 浙江工业大学药学院制药工程教育部重点实验室,浙江杭州,310014 |
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| 基金项目： | 浙江省教育厅科研计划项目(Y200908144); 科技部国际科技合作项目(2008DFR40280) |
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| 摘 要： | 研究了甲壳素超微粉碎辅助制备D-氨基葡萄糖盐酸盐（GAH）的工艺。对HCl浓度、反应时间、反应温度和液料比进行单因素考察,根据考察结果进行Box-Benhnken中心组合设计,利用响应面分析法优化工艺参数,然后进行验证实验,并将该工艺条件与传统GAH制备工艺比较。结果表明,甲壳素超微粉碎辅助制备GAH的较佳工艺为：HCl浓度8.8mol/L、液料比4.2∶1（mL∶g）、反应时间3.6h、反应温度83.0℃。此条件下GAH得率为74.82%,与理论值基本相符。与传统制备工艺相比,新工艺反应条件更加温和,同时GAH得率提高了14.77%。
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| 关 键 词： | 甲壳素 超微粉碎 D-氨基葡萄糖盐酸盐(GAH) 响应面分析 |
Superfine comminution assisted preparation of D-Glucosamine hydrochloride from chitin |
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| ZHU Xing-yi,ZHANG Yu-yan,XIE Jie,WANG Ping.Superfine comminution assisted preparation of D-Glucosamine hydrochloride from chitin[J].Science and Technology of Food Industry,2011(11):321-324. |
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| Authors: | ZHU Xing-yi ZHANG Yu-yan XIE Jie WANG Ping |
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| Affiliation: | ZHU Xing-yi,ZHANG Yu-yan,XIE Jie,WANG Ping(College of Pharmaceutical Sciences,Zhejiang University of Technology,Key Laboratory of Pharmaceutical Engineering of Ministry of Education,Hangzhou 310014,China) |
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| Abstract: | The operating factors affecting the yield of D-Glucosamine hydrochloride(GAH)from chitin by superfine comminution assisted preparation(SCAP)were studied.Firstly,single factors including HCl concentration,solid-liquid ratio,reaction time and reaction temperature were investigated seperately,then the response surface analysis method followed by the verification tests was conducted for obtaining the appropriate operation conditions.Finally,the SCAP method was compared with the traditional preparation method.Re... |
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| Keywords: | chitin superfine comminution D-Glucosamine hydrochloride(GAH) response surface analysis |
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