Modeling and simulation of a SMB chromatographic process designed for enantioseparation |
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| Affiliation: | 1. Laboratoire d’Automatique, Faculté Polytechnique de Mons, Boulevard Dolez 31, 7000 Mons, Belgium;2. Chaire de Technologie Chimique, Université de Mons-Hainaut, Belgium;3. Service de Mathématique, Faculté Polytechnique de Mons, Belgium;1. School of Engineering Science, Lappeenranta University of Technology, Skinnarilankatu 34, FIN-53850 Lappeenranta, Finland;2. UPM-Kymmene Corporation, North European Research Center, Biochemicals, Paloasemantie 19, FIN-53200 Lappeenranta, Finland;1. College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China;2. National Engineering Technique Research Center for Biotechnology, Nanjing, China;3. Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing, China;4. State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing, China |
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| Abstract: | This paper focuses on modeling of a simulated moving bed process (SMB) dedicated to the separation of racemic mixtures. In the first approach, a true moving bed model is derived, which assumes an equivalent counter-current movement of the solid phase. The good agreement between the model and the real system is demonstrated with experimental results. Then, a more rigorous approach is developed, which considers the system as an arrangement of static chromatographic columns and takes into account periodic switching. Attention is focused on model formulation and numerical solution techniques in order to develop efficient dynamic simulation programs. |
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