| Aspartame的合成中间体—N—甲酰基—L—天冬氨酸酐的合成研究 |
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| 引用本文： | 张灏,吴卫忠,陈建海,李辰,赵文娟. Aspartame的合成中间体—N—甲酰基—L—天冬氨酸酐的合成研究[J]. 精细石油化工进展, 2000, 1(8): 16-18 |
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| 作者姓名： | 张灏 吴卫忠 陈建海 李辰 赵文娟 |
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| 作者单位： | 江苏石油化工学院化工系 |
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| 摘 要： | 研究了由－天冬氨酸和甲酸反应制备Ａｓｐａｒｔａｍｅ的重要中间体－－Ｎ甲酰基－Ｌ－天冬氨酸酐的方法。通过考察反应物的配比、反应温度及反应等对应的影响，确定 最佳反应条件，使Ｎ－甲酰基－Ｌ－天冬氨酸中成收率达到９８％。
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| 关 键 词： | 天冬氨酸 甲酰基 天冬氨酸酐 甲酰基化 |
| 修稿时间： | 2000-06-29 |
Study on Synthesis of N-Formyl-L-Aspartic Anhydride as Intermediate for Aspartame |
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| Zhang Hao Wu Weizhong Chen Jianhai Li Chen Zhao Wenjuan. Study on Synthesis of N-Formyl-L-Aspartic Anhydride as Intermediate for Aspartame[J]. Advances in Fine Petrochemicals, 2000, 1(8): 16-18 |
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| Authors: | Zhang Hao Wu Weizhong Chen Jianhai Li Chen Zhao Wenjuan |
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| Abstract: | The method of synthesizing N -formyl- L -aspartic anhydride as intermediate for aspartame was synthesized by reaction of L -aspartic acid with formic acid was studied. The optimum conditions were determined by examining the effects of molar ratio of reactant,reaction time, and reaction tem-perature on the reaction withyield of N -formyl- L -aspartic anhydride up to 98%. |
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| Keywords: | aspartame L -aspartic acid N -formyl- L -aspartic anhydride formylation synthesis |
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